In a September 22, 2026 report, NASA said four Expedition 75 crewmates were preparing to return to Earth aboard a SpaceX Dragon the following month, while their Crew-13 replacements were due to launch as soon as early October. NASA astronauts Jessica Meir and Jack Hathaway, ESA astronaut Sophie Adenot and Roscosmos cosmonaut Andrey Fedyaev, the Crew-12 quartet, trained Tuesday on undocking and descent procedures and checked their pressure suits ahead of a Pacific splashdown. Meir also staged emergency breathing gear ahead of Crew-13's arrival.

NASA flight engineer Anil Menon collected blood and saliva samples for the Immunity Assay investigation, which is intended to help doctors understand how microgravity affects astronauts' ability to fight infections and disease. Roscosmos flight engineers Pyotr Dubrov and Annan Kikina continued unloading some of the nearly three tons of food, fuel and supplies delivered Saturday by the Progress 96 cargo craft, and Dubrov configured Earth imaging gear.

Fedyaev downloaded Earth imagery captured during the crew's sleep shift and serviced the camera gear, then later helped unload Progress 96 cargo. The plans were reported as of the source date.