UNICEF South Sudan said on 3 November 2026 that it was on alert for further outbreaks of Ebola, Bundibugyo Virus Disease (BVD), after cases in neighbouring countries including the Democratic Republic of Congo, and was scaling up preparedness in priority counties. The agency reported delivering over 50 metric tonnes of supplies, including Personal Protective Equipment and infection-control materials, with support from the United States Government, Mastercard Foundation and the UN Central Emergency Revolving Fund.

In the most at-risk counties and states, UNICEF said it was improving infection-prevention standards and training health workers, rapid response teams, faith leaders and community members to identify symptoms, support early referral and combat misinformation. A national simulation exercise led by the National Public Health Institute and the Ministry of Health identified strengths and gaps in a system-wide response. UNICEF's Douglas Noble said the priority was to address remaining gaps, while representative Noala Skinner called for additional investment in community-based surveillance, health facility readiness, supply pipelines, cross-border preparedness and surge capacity.

UNICEF noted Bundibugyo is a rare and different type of Ebola with no specific treatment, though trials are underway. It reported that as of 1 November 2026, more than 10,000 people were infected with BVD in DRC, where more than 5,000 had died, and that one in four cases and one in three deaths there were children.